Informatics Publishing Limited

Namdeo G. Shinde ¹, Bhaskar N. Bangar ¹, Sunil M. Deshmukh ¹, Suyog P. Sulake ¹, Dipak P. Sherekar ²

Affiliations
1 Department of Pharmaceutics, Satara College of Pharmacy, Degaon, Satara-415004, (MS), IN
2 Satara College of Pharmacy, Degaon, Satara-415004, (MS), IN

Abstract

Forced degradation is a powerful tool used routinely in pharmaceutical development in order to develop stabilityindicating methods that lead to quality stability data and to understand the degradation pathways of the drug substances and drug products. These experiments generally expose the material to an external stress to assess the stability of the constituents or formulation. External Stress mainly includes temperature, pH, light, moisture, and even exposure to other materials within the product formulation, and their degradation products. Conventionally, degradation tests can take very long periods of time, because standard test methods require the materials to be exposed to stress factors for periods of weeks or longer, and then tested using standard analytical methods. Accelerated testing is of clear benefit, as use of elevated temperature to increase the rate of interactions is the most powerful factor to shorten the length of time required for these tests. Forced degradation studies ensure appropriate stability of final pharmaceutical products in very early stages of pharmaceutical development.

Keywords

Forced Degradation Study, Active Pharmaceutical Ingredient (API), and International Conference on Harmonization (ICH).

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Namdeo G. Shinde ¹, Nayana V. Pimpodkar ²

Affiliations
1 Department of Pharmaceutics, Satara College of Pharmacy, Degaon, Satara-415004, (MS), IN
2 Satara College of Pharmacy (D. Pharm), Degaon, Satara-415004, (MS), IN

Abstract

The chemistry of heterocyclic compound is one of the most complex branch of organic chemistry, which is equally interesting for its theoretical Implications, for the delivery of its synthetic procedures and for physiological and industrial significance of heterocyclic compound. Pyrazole has been studied for over a century as an important class of heterocyclic compound and continue to attract considerable interest due to the broad range of biological activities they posses. Present review highlighted recent reports of various pharmacological activities of pyrazole and its derivatives. Several pyrazole derivatives in the literature showed important biological activities with their structures are covered in this review.

Keywords

Pyrazole Derivatives, Heterocyclic Aromatic Compounds, Pharmacological Activities.

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Namdeo G. Shinde ¹, Nagesh H. Aloorkar ¹, Ajit S. Kulkarni ¹

Affiliations
1 Department of Pharmaceutics, Satara College of Pharmacy, Degaon, Satara-415004, (MS), IN

Abstract

Designing of the drug in the vesicular system has brought a new life to the pre-existing drugs and thus has improved their therapeutic efficacies by controlling and sustaining the actions. This article mainly focuses on recent advances in vesicular drug delivery system. Consequently a number of vesicular drug delivery systems like liposomes, niosomes, transfersomes, pharmacosomes, ethosomes, sphingosomes, colloidosomes, herbosomes and cubosomes etc. have been developed. Every new system shows one or more advantages over the older vesicular systems. The era of vesicular delivery has much to explore by achieving success in various upcoming systems such as aquasomes, cryptosmes, emulsomes, enzymosome, genosomes, photosomes, virosomes, vesosomes, proteosomes etc. The approaches like provesicular drug delivery, coating of vesicles, layerosomes, ufasomes system etc have also been developed which have better stabilities in comparison to simple vesicular drug delivery systems. In recent years, the intravesical route has also been exploited either as an adjunct to an oral regimen or as a second-line treatment for Neurogenic bladder.

Keywords

Vesicular Drug Delivery System, Sphingosomes, Herbosomes, Ufasomes, Genosomes, Enzymosome Etc.

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